反应详情

To a solution of 3.0 g of sodium hydride (50% dispersion in oil) in 300 ml of anhydrous tetrahydrofuran under argon was added 14.0 g of N-[3-(6-chloro-3-pyridazinyl)phenyl]acetamide. The solution was stirred for 0.5 hours, then 3.9 ml of methyl iodide was added. After stirring for 2 hours, the solution was poured onto 400 ml of water and extracted with 100 ml portions of dichloromethane. The combined extracts were dried, concentrated in vacuo and chromatographed on hydrated magnesium silicate with dichloromethane-methanol (98:2) as eluant. The fractions containing the desired product were combined, concentrated in vacuo and recrystalized from acetone-hexane to give 14.1 g of cream crystals, mp 109°-112° C.

1. stirringAfter stirring for 2 hours
2. extractionextracted with 100 ml portions of dichloromethane
3. customThe combined extracts were dried
4. concentrationconcentrated in vacuo
5. customchromatographed on hydrated magnesium silicate with dichloromethane-methanol (98:2) as eluant
6. additionThe fractions containing the desired product
7. concentrationconcentrated in vacuo
8. customrecrystalized from acetone-hexane