反应详情

A solution of 2-(5-acetylamino-2-methoxyphenyl)-1,3-dioxolane (5.0 g, 21.1 mmol) in DMF (16 ml) was added to a suspension of NaH (1.0 g, 25.3 mmol) in DMF (5 ml) and then the mixture was stirred at room temperature for 10 min. To the mixture was added methyl iodide (3.6 g, 25.3 mmol) and then stirred at room temperature for 1 hr. And to the resulted reaction mixture was added ammonium chloride and then extracted with CH2Cl2. The extract was washed with water and brine, dried over Na2SO4 and concentrated in vacuo to give crude 2-[5-(N-acetyl-N-methylamino)-2-methoxyphenyl]-1,3-dioxolane (5.0 g, 94%) as a orange oil.

1. stirringstirred at room temperature for 1 hr
2. customAnd to the resulted reaction mixture
3. extractionextracted with CH2Cl2
4. washThe extract was washed with water and brine
5. dry with materialdried over Na2SO4
6. concentrationconcentrated in vacuo