反应详情

温度

75 °C

To a solution of (1aR-cis)-1a,7b-dihydro-2,2-dimethyl-2H-oxireno-[c][1]benzopyran-6-carbonitrile ((2.5 g, 12.4 mmol, the title A compound of Example 3) in tetrahydrofuran in a re-sealable tube was added concentrated ammonium hydroxide (2 mL). The tube was sealed and the solution was heated on an oil bath at 75° C. overnight. The resultant solution was cooled to room temperature, concentrated and extracted with ethyl acetate. The combined organic extracts were dried over anhydrous sodium sulfate and concentrated to yield the title compound as an oil.

1. customThe tube was sealed
2. concentrationconcentrated
3. extractionextracted with ethyl acetate
4. dry with materialThe combined organic extracts were dried over anhydrous sodium sulfate
5. concentrationconcentrated