反应详情

温度

55 °C

According to the method of J. Bergman et al. Tet. 29, 971-976 (1973), combine indole (11.7 g, 100 mmol), pyridine (8.1 mL, 100 mmol), and toluene (250 mL). Heat to 55° C. Add dropwise a solution of chloroacetyl chloride (8 mL, 100 mmol) in toluene (10 mL). After 2 hours, cool to ambient temperature. Dilute the reaction mixture with ethyl acetate and extract with water. Dry the organic layer over MgSO4, filter and evaporate in vacuo to give a residue. Recrystallize the residue from ethanol to give the title compound.

1. temperaturecool to ambient temperature
2. extractionextract with water
3. dry with materialDry the organic layer over MgSO4
4. filtrationfilter
5. customevaporate in vacuo
6. customto give a residue
7. customRecrystallize the residue from ethanol