反应详情

温度

70 °C

Under a dry nitrogen atmosphere a stirred mixture of 10.9 g (0.077 mole) 4-fluoronitrobenzene, 9.95 g (0.0077 mole) 4-chlorophenol, and 11.8 g (0.085 mole) potassium carbonate in 175 mL of dimethylsulfoxide was heated at 70° C. for two days. The reaction mixture was cooled and filtered. The filtrate was diluted with water until a volume of one liter was obtained. This mixture was extracted with three 200 mL portions of diethyl ether. The combined ether extract was washed with water followed by an aqueous saturated sodium chloride solution. The washed extract was dried over anhydrous sodium sulfate and filtered. Evaporation of the filtrate under reduced pressure yielded 13.5 g 4-(4-chlorophenoxy)nitrobenzene (mp 67°-70° C.).

1. temperatureThe reaction mixture was cooled
2. filtrationfiltered
3. additionThe filtrate was diluted with water until a volume of one liter
4. customwas obtained
5. extractionThis mixture was extracted with three 200 mL portions of diethyl ether
6. extractionThe combined ether extract
7. washwas washed with water
8. extractionThe washed extract
9. dry with materialwas dried over anhydrous sodium sulfate
10. filtrationfiltered
11. customEvaporation of the filtrate under reduced pressure