反应详情

温度

60 °C

A stirred solution of 5-bromo-2-methoxyphenol (74 g) and anhydrous potassium carbonate (73.6 g) in dry dimethylformamide (500 mL) is treated with cyclopentyl bromide (80.5 g) and the solution is heated at 60° C. for 16 hours. It is then concentrated, and the resulting residue is triturated with water (250 mL), and extracted with dichloromethane (3×250 mL). The combined extracts are dried and evaporated, to give 3-cyclopentyloxy-4-methoxyphenyl bromide (95.5 g), in the form of a light brown oil.

1. concentrationIt is then concentrated
2. customthe resulting residue is triturated with water (250 mL)
3. extractionextracted with dichloromethane (3×250 mL)
4. customThe combined extracts are dried
5. customevaporated