Triethylamine → HCID 18936711, compound

HRID 357007Notes

Reaction equation

HRID 357007 reaction equation
Cl.[OH:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]1[N:12]2[CH:13]=[CH:14][N:15]=[C:11]2[CH:10]=[CH:9][CH:8]=1.C(N(CC)CC)C.[CH3:23][S:24](Cl)(=[O:26])=[O:25].C(=O)([O-])O.[Na+]>ClCCl>[CH3:23][S:24]([O:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]1[N:12]2[CH:13]=[CH:14][N:15]=[C:11]2[CH:10]=[CH:9][CH:8]=1)(=[O:26])=[O:25]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 516892Sodium BicarbonateHCID 18936877HCID 18936877, compound

Product 1

HCID 18936711HCID 18936711, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1.59 g (7.0 mmol) of 5-(4-hydroxybutyl)imidazo[1,2-a]pyridine hydrochloride and 2.25 ml (16 mmol) of triethylamine in 30 ml of dichloromethane, 0.62 ml (8.0 mmol) of methanesulfonyl chloride was added at 0° C. After stirring at room temperature for 1 hour, saturated aqueous sodium hydrogen carbonate was added. The reaction mixture was extracted with dichloromethane and dried, after which the solvent was distilled off to yield 5-(4-methanesulfonyloxybutyl)imidazo[1,2-a]pyridine.

Workup

  1. extractionThe reaction mixture was extracted with dichloromethane
  2. customdried
  3. distillationafter which the solvent was distilled off

Sources & evidence

ORD record
ord-c7c6d6631d9a4602be1e0616c83f4c2e
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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