Hydrochloric Acid → 5-Butylidene-3-[2-(imidazo[1,2-a]pyridin-5-yl)ethyl]thiazolidine-2,4-dione hydrochloride

HRID 357057Notes

Reaction equation

HRID 357057 reaction equation
[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][C:13]2[N:18]3[CH:19]=[CH:20][N:21]=[C:17]3[CH:16]=[CH:15][CH:14]=2)[C:6]1=[O:22])[CH2:2][CH2:3][CH3:4].[ClH:23]>CO>[ClH:23].[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][C:13]2[N:18]3[CH:19]=[CH:20][N:21]=[C:17]3[CH:16]=[CH:15][CH:14]=2)[C:6]1=[O:22])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 572923195-Butylidene-3-[2-(imidazo[1,2-a]pyridin-5-yl)ethyl]thiazolidine-2,4-dione

Product 1

HCID 734729075-Butylidene-3-[2-(imidazo[1,2-a]pyridin-5-yl)ethyl]thiazolidine-2,4-dione hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1.15 g (3.65 mmol) of 5-butylidene-3-[2-(imidazo[1,2-a]pyridin-5-yl)ethyl]thiazolidine-2,4-dione in 50 ml of methanol, 0.33 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 1.00 g (77.9%, light yellow solid) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-393521cebc0b49828745cff280617e15
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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