Hydrochloric Acid → HCID 73472900, compound

HRID 357096Notes

Reaction equation

HRID 357096 reaction equation
[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][O:15][C:16]2[C:17]3[N:18]([C:22]([C:25](=[O:30])[C:26]([F:29])([F:28])[F:27])=[CH:23][N:24]=3)[CH:19]=[CH:20][CH:21]=2)[C:6]1=[O:31])[CH2:2][CH2:3][CH3:4].[ClH:32]>CO>[ClH:32].[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][O:15][C:16]2[C:17]3[N:18]([C:22]([C:25](=[O:30])[C:26]([F:27])([F:29])[F:28])=[CH:23][N:24]=3)[CH:19]=[CH:20][CH:21]=2)[C:6]1=[O:31])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57245948HCID 57245948, compound

Product 1

HCID 73472900HCID 73472900, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 250 mg (0.55 mmol) of 5-butylidene-3-[4-(3-trifluoroacetylimidazo[1,2-a]pyridin-8-yloxy)butyl]-thiazolidine-2,4-dione in 5 ml of methanol, 0.05 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 290 mg (100%, white solid) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-f88b08e21e0a421ca83da02795de3e3a
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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