Hydrochloric Acid → HCID 86753349, compound

HRID 357136Notes

Reaction equation

HRID 357136 reaction equation
[C:1]([CH:6]=[C:7]1[S:11][C:10](=[O:12])[N:9]([CH2:13][CH2:14][CH2:15][CH2:16][S:17][C:18]2[N:23]3[CH:24]=[CH:25][N:26]=[C:22]3[CH:21]=[CH:20][CH:19]=2)[C:8]1=[O:27])([O:3][CH2:4][CH3:5])=[O:2].[ClH:28]>CO>[ClH:28].[C:1]([CH:6]=[C:7]1[S:11][C:10](=[O:12])[N:9]([CH2:13][CH2:14][CH2:15][CH2:16][S:17][C:18]2[N:23]3[CH:24]=[CH:25][N:26]=[C:22]3[CH:21]=[CH:20][CH:19]=2)[C:8]1=[O:27])([O:3][CH2:4][CH3:5])=[O:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 545656045-Carboethoxymethylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione

Product 1

HCID 86753349HCID 86753349, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 0.70 g (1.73 mmol) of 5-carboethoxymethylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione in 20 ml of methanol, 0.20 ml of concentrated hydrochloric acid was added, followed by stirring, after which the solvent was distilled off. The residue was washed with diethyl ether to yield 0.74 g (96.8%, white solid) of the desired product.

Workup

  1. distillationafter which the solvent was distilled off
  2. washThe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-2369fe53fef34bbeb5d1fcb2db1d9feb
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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