Hydrochloric Acid → 5-Butylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylsulfinyl)butyl]thiazolidine-2,4-dione hydrochloride

HRID 357139Notes

Reaction equation

HRID 357139 reaction equation
[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][S:15]([C:17]2[N:22]3[CH:23]=[CH:24][N:25]=[C:21]3[CH:20]=[CH:19][CH:18]=2)=[O:16])[C:6]1=[O:26])[CH2:2][CH2:3][CH3:4].[ClH:27]>CO>[ClH:27].[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][S:15]([C:17]2[N:22]3[CH:23]=[CH:24][N:25]=[C:21]3[CH:20]=[CH:19][CH:18]=2)=[O:16])[C:6]1=[O:26])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 573057195-Butylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylsulfinyl)butyl]thiazolidine-2,4-dione

Product 1

HCID 734729145-Butylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylsulfinyl)butyl]thiazolidine-2,4-dione hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 287 mg (0.73 mmol) of 5-butylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylsulfinyl)butyl]thiazolidine-2,4-dione in 10 ml of methanol, 0.10 ml of concentrated hydrochloric acid was added, followed by stirring, after which the solvent was distilled off. The residue was washed with diethyl ether to yield 280 mg (89.6%, light yellow foamy substance) of the desired product.

Workup

  1. distillationafter which the solvent was distilled off
  2. washThe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-8960f2c2765742829c8f96599e461e13
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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