反应详情

温度

80 °C

To a solution of 601 mg (2.5 mmol) of 5-(4-chlorobutylthio)imidazo[1,2-a]pyridine and 473 mg (2.5 mmol) of 5-(ethylthiomethylene)thiazolidine-2,4-dione in 5 ml of N,N-dimethylformamide, 0.37 ml (2.5 mmol) of 1,8-diazabicyclo[5.4.0]-7-undecene was added, followed by stirring at 80° C. for 16 hours. After the reaction mixture was cooled, water was added; the mixture was extracted with ethyl acetate and dried, after which the solvent was distilled off. The residue was purified by column chromatography (eluent, hexane/ethyl acetate=1/4→ethyl acetate) to yield 0.76 g (77.2%, light orange oily substance) of the desired product.

1. temperatureAfter the reaction mixture was cooled
2. extractionthe mixture was extracted with ethyl acetate
3. customdried
4. distillationafter which the solvent was distilled off
5. customThe residue was purified by column chromatography (eluent, hexane/ethyl acetate=1/4→ethyl acetate)