Hydrochloric Acid → HCID 73472979, compound

HRID 357163Notes

Reaction equation

HRID 357163 reaction equation
[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][C:13]([CH3:27])([CH3:26])[CH2:14][CH2:15][S:16][C:17]2[N:22]3[CH:23]=[CH:24][N:25]=[C:21]3[CH:20]=[CH:19][CH:18]=2)[C:6]1=[O:28])[CH2:2][CH2:3][CH3:4].[ClH:29]>CO>[ClH:29].[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][C:13]([CH3:27])([CH3:26])[CH2:14][CH2:15][S:16][C:17]2[N:22]3[CH:23]=[CH:24][N:25]=[C:21]3[CH:20]=[CH:19][CH:18]=2)[C:6]1=[O:28])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57190382HCID 57190382, compound

Product 1

HCID 73472979HCID 73472979, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 310 mg (0.74 mmol) of 5-butylidene-3-[5-(imidazo[1,2-a]pyridin-5-ylthio)-3,3-dimethylpentyl]thiazolidine-2,4-dione in 5 ml methanol, 0.01 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 320 mg (95.0%, light yellow solid) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-3e76545827b3499ea20f83740bb698d9
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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