Hydrochloric Acid → HCID 73472904, compound

HRID 357169Notes

Reaction equation

HRID 357169 reaction equation
[CH:1](=[C:6]1[S:10][C:9](=[O:11])[N:8]([CH2:12][CH2:13][CH2:14][CH2:15][S:16][C:17]2[N:22]3[CH:23]=[CH:24][N:25]=[C:21]3[CH:20]=[CH:19][CH:18]=2)[C:7]1=[O:26])[CH2:2][CH2:3][CH2:4][CH3:5].[ClH:27]>CO>[ClH:27].[CH:1](=[C:6]1[S:10][C:9](=[O:11])[N:8]([CH2:12][CH2:13][CH2:14][CH2:15][S:16][C:17]2[N:22]3[CH:23]=[CH:24][N:25]=[C:21]3[CH:20]=[CH:19][CH:18]=2)[C:7]1=[O:26])[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57320792HCID 57320792, compound

Product 1

HCID 73472904HCID 73472904, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1.70 g (4.36 mmol) of 5-pentylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione in 30 ml of methanol, 0.42 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 1.77 g (95.3%, yellow-orange oily substance) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-c147796933a849d194791c174ecae39f
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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