Hydrochloric Acid → 5-Ethylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]oxazolidine-2,4-dione hydrochloride

HRID 357180Notes

Reaction equation

HRID 357180 reaction equation
[CH:1](=[C:3]1[O:7][C:6](=[O:8])[N:5]([CH2:9][CH2:10][CH2:11][CH2:12][S:13][C:14]2[N:19]3[CH:20]=[CH:21][N:22]=[C:18]3[CH:17]=[CH:16][CH:15]=2)[C:4]1=[O:23])[CH3:2].[ClH:24]>CO>[ClH:24].[CH:1](=[C:3]1[O:7][C:6](=[O:8])[N:5]([CH2:9][CH2:10][CH2:11][CH2:12][S:13][C:14]2[N:19]3[CH:20]=[CH:21][N:22]=[C:18]3[CH:17]=[CH:16][CH:15]=2)[C:4]1=[O:23])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 570805305-Ethylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]oxazolidine-2,4-dione

Product 1

HCID 702025975-Ethylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]oxazolidine-2,4-dione hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 77 mg (0.23 mmol) of 5-ethylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]oxazolidine-2,4-dione in 5 ml of methanol, 0.10 ml of concentrated hydro-chloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 90 mg (quant., brown oily substance) of the desired product.

Workup

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with diethyl ether

Sources & evidence

ORD record
ord-2165adceff1344e6a14c29b07df924a7
Source dataset
uspto-grants-1998_11
Patent number
US05840732

Reaction notes

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