反应详情

To a solution of 4.0 g of the monoacetate of ganciclovir in 5 ml of isopropyl acetate and 5 ml of dimethylformamide was added 4.1 g of Z-valine-NCA and 0.08 g of 4-dimethylaminopyridine (DMAP). The solution was stirred for 3 hours at room temperature. An additional 0.8 g of Z-valine-NCA was added and stirring was continued for 1 hour. The solution was drowned with 75 ml of isopropyl acetate and stirred for 3 hours. The reaction mixture was then filtered and washed twice with 10 ml each of isopropyl acetate. The product was dried in a vacuum oven at ca. 500 mm of Hg (torr), (nitrogen sweep, 60°) overnight to give 5.6 g of Z-valine-ganciclovir monoacetate.

1. stirringstirring
2. waitwas continued for 1 hour
3. stirringstirred for 3 hours
4. filtrationThe reaction mixture was then filtered
5. washwashed twice with 10 ml each of isopropyl acetate
6. customThe product was dried in a vacuum oven at ca. 500 mm of Hg (torr), (nitrogen sweep, 60°) overnight