Hydrochloric Acid → Benzenecarboximidic acid, 3-acetyl-, ethyl ester, hydrochloride

HRID 357628Notes

Reaction equation

HRID 357628 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[C:7]#[N:8])(=[O:3])[CH3:2].[CH2:12]([OH:14])[CH3:13].[ClH:15]>C(OCC)C>[ClH:15].[CH2:12]([O:14][C:7](=[NH:8])[C:6]1[CH:9]=[CH:10][CH:11]=[C:4]([C:1](=[O:3])[CH3:2])[CH:5]=1)[CH3:13]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 802223-Acetylbenzonitrile

Product 1

HCID 12289426Benzenecarboximidic acid, 3-acetyl-, ethyl ester, hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 7.25 g (0.05 mol) of 3-acetylbenzonitrile (Aldrich, Buchs, Switzerland; Cat. No. 29,221-4) in 150 ml of diethyl ether and 4.5 ml of ethanol is saturated at 0° C. with dry hydrochloric acid gas and then left to stand at 0° C. for 2 days. The product that has crystallized out is filtered off and the title compound is obtained after recrystallization from ethanol/diethyl ether, m.p. 110° C. (decomp.).

Workup

  1. waitleft
  2. customThe product that has crystallized out
  3. filtrationis filtered off

Sources & evidence

ORD record
ord-8d361d0a4c154a149f4e969a52691a6b
Source dataset
uspto-grants-1998_11
Patent number
US05840911

Reaction notes

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