Sodium Hydroxide → HCID 18937673, compound

HRID 357652Notes

Reaction equation

HRID 357652 reaction equation
[CH3:1][O:2][C:3]1[CH:32]=[CH:31][C:6]([CH2:7][N:8]2[C:12]([C:13](=[O:25])[C:14]3[CH:19]=[C:18]([CH3:20])[C:17]([CH3:21])=[CH:16][C:15]=3[N+:22]([O-:24])=[O:23])=[C:11]([C:26]([O:28]CC)=[O:27])[N:10]=[N:9]2)=[CH:5][CH:4]=1.[OH-].[Na+]>O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][N:8]2[C:12]([C:13](=[O:25])[C:14]3[CH:19]=[C:18]([CH3:20])[C:17]([CH3:21])=[CH:16][C:15]=3[N+:22]([O-:24])=[O:23])=[C:11]([C:26]([OH:28])=[O:27])[N:10]=[N:9]2)=[CH:31][CH:32]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18937804HCID 18937804, compound

Product 1

HCID 18937673HCID 18937673, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the same manner as above, a solution of ethyl 1-(4-methoxybenzyl)-5-(4,5-dimethyl-2-nitrobenzoyl)-1,2,3-triazole-4-carboxylate (b-2) (2.48 g, 5.66 mmole) in tetrahydrofuran (30 ml) was hydrolyzed with a 1N aqueous sodium hydroxide solution (11.3 ml) at room temperature for 3 hours to give 1-(4-methoxybenzyl)-5-(4,5-dimethyl-2-nitrobenzoyl)-1,2,3-triazole-4-carboxylic acid (c-2': MP) as a crude product of brownish oil (2.448 g).

Sources & evidence

ORD record
ord-e7f3304466384ebb80e69ed303787a32
Source dataset
uspto-grants-1998_11
Patent number
US05840895

Reaction notes

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