Diisopropyl Ether → (R)-2-bromo-1-(3-chlorophenyl)ethanol

HRID 357724Notes

Reaction equation

HRID 357724 reaction equation
C(OC(C)C)(C)C.[Br:8][CH2:9][CH:10]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=1)[OH:11]>>[Br:8][CH2:9][C@@H:10]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=1)[OH:11]

Participants

3

Reactant 2

HCID 7914Diisopropyl EtherHCID 99646942-Bromo-1-(3-chlorophenyl)ethanol

Product 1

HCID 11075396(R)-2-bromo-1-(3-chlorophenyl)ethanol

Procedure

Diisopropyl ether was added to a mixture of 100 mg (0.4 mmol) of 2-bromo-1-(3-chlorophenyl)ethanol, 20 mg of TOYOCHIMU LIP (available from Toyobo Co., Ltd.) and 0.3 mmol of each of the various acid anhydrides shown in Table 3 was to make the total volume to 1 ml. These reaction mixtures were respectively allowed to undergo reaction at a temperature of 27° C. for 98 hours. The results are set forth in Table 3.

Workup

  1. customThese reaction mixtures
  2. customreaction at a temperature of 27° C. for 98 hours

Sources & evidence

ORD record
ord-8af97dab936b4dbda8044b95a5688946
Source dataset
uspto-grants-1998_11
Patent number
US05841001

Reaction notes

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