N-Methylaniline → HCID 12774510, compound

HRID 358032Notes

Reaction equation

HRID 358032 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[CH3:13][NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(O)C>[ClH:1].[Cl:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([N:14]([CH3:13])[C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[N:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 7515N-MethylanilineHCID 2418814,7-Dichloroquinazoline

Product 1

HCID 12774510HCID 12774510, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3.0 g of 4,7-dichloroquinazoline and 1.7 g of N-methylaniline in 10 ml of ethanol was heated for 10 minutes. After completion of the reaction, the ethanol was distilled off and the resulting crystals were recrystallized from a small amount of ethanol to give 2.4 g (yield 46%) of the desired Compound No. 56 in the form of pale yellow granules melting at 230°-233° C. (with decomposition).

Workup

  1. customAfter completion of the reaction
  2. distillationthe ethanol was distilled off
  3. customthe resulting crystals were recrystallized from a small amount of ethanol

Sources & evidence

ORD record
ord-f4299391dc3547a9bf659de15d12ec93
Source dataset
uspto-grants-1984_08
Patent number
US04464375

Reaction notes

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