Hydrochloric Acid → HCID 73509636, compound

HRID 358043Notes

Reaction equation

HRID 358043 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11](=O)[CH2:10][CH2:9]1.Cl.[NH2:20][OH:21].[OH-].[Na+].Cl>C(O)C.O>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11](=[N:20][OH:21])[CH2:10][CH2:9]1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 129391754-(2-Fluorophenyl)-3,4-dihydronaphthalen-1(2H)-one

Product 1

HCID 73509636HCID 73509636, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

32 g of 4-(2-fluorophenyl)-1-tetralone in 75 ml of ethanol are treated with a solution of 9.26 g of hydroxylamine hydrochloride in 10 ml of water and then with 17 g of powdered sodium hydroxide. The mixture is heated to boiling under reflux for 5 minutes, again cooled and then poured into a mixture of ice and dilute hydrochloric acid. The mixture is extracted with ether and the extract obtained is washed with water. After evaporation of the solvent, there is obtained 4-(2-fluorophenyl)-1-tetralone oxime of melting point 120°.

Workup

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 5 minutes
  3. temperatureagain cooled
  4. extractionThe mixture is extracted with ether
  5. customthe extract obtained
  6. washis washed with water
  7. customAfter evaporation of the solvent

Sources & evidence

ORD record
ord-ed023702493a44a5ac31adbbc6b8cb54
Source dataset
uspto-grants-1984_08
Patent number
US04464300

Reaction notes

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