Hydrazine hydrate (1:1) → HCID 20450022, compound

HRID 358066Notes

Reaction equation

HRID 358066 reaction equation
O.[NH2:2][NH2:3].[Cl:4][C:5]1[CH:6]=[CH:7][C:8]2[NH:15][C:14](=S)[CH2:13][CH2:12][S:11](=[O:18])(=[O:17])[CH:10]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[F:25])[C:9]=2[CH:26]=1>O1CCCC1>[Cl:4][C:5]1[CH:6]=[CH:7][C:8]2[N:15]=[C:14]([NH:2][NH2:3])[CH2:13][CH2:12][S:11](=[O:18])(=[O:17])[CH:10]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[F:25])[C:9]=2[CH:26]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20449993HCID 20449993, compound

Product 1

HCID 20450022HCID 20450022, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 0.9 ml of hydrazine hydrate in 134 ml of tetrahydrofuran is treated with 6.2 g of 8-chloro-6-(2-fluorophenyl)-1,3,4,6-tetrahydro-2-thiono-2H-5,1-benzothiazocine 5,5-dioxide. The solution is stirred at room temperature under a stream of argon for 1.25 hours and then evaporated in vacuo. The residue is crystallized from diisopropyl ether, there being obtained 8-chloro-6-(2-fluorophenyl)-2-hydrazino-3,6-dihydro-4H-5,1-benzothiazocine 5,5-dioxide of melting point 159°.

Workup

  1. customevaporated in vacuo
  2. customThe residue is crystallized from diisopropyl ether, there

Sources & evidence

ORD record
ord-3ba008467bdb4245acc949d80575a6af
Source dataset
uspto-grants-1984_08
Patent number
US04464300

Reaction notes

Loading…