反应详情

A mixture of Dioxolane (B-5)(1.62 g), tetraethylammonium fluoride dihydrate (1.38 g) and acetic acid (0.5 ml) in tetrahydrofuran (10 ml) is stirred at room temperature for 2 hours. The reaction mixture is diluted with ethyl acetate (50 ml), washed with saturated saline, dried and concentrated. The residue purified by silica gel chromatography to give tilted Lactam (C-5)(895 mg) from the fractions eluted with benzene-ethyl acetate (1:5).

1. washwashed with saturated saline
2. customdried
3. concentrationconcentrated
4. customThe residue purified by silica gel chromatography
5. customto give
6. washeluted with benzene-ethyl acetate (1:5)