Hydroxyamine hydrochloride → HCID 86739589, compound

HRID 358171Notes

Reaction equation

[C:1]([C:8]1[C:9]([NH:19][CH3:20])=[C:10]([C:14](=O)[C:15]([OH:17])=[O:16])[CH:11]=[CH:12][CH:13]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].Cl.[NH2:22][OH:23]>>[C:1]([C:8]1[C:9]([NH:19][CH3:20])=[C:10]([C:14](=[N:22][OH:23])[C:15]([OH:17])=[O:16])[CH:11]=[CH:12][CH:13]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 70509511HCID 70509511, compound

Product 1

HCID 86739589HCID 86739589, compound

Procedure

32.2 g of 2-(3-BOC-methylaminophenyl)-glyoxylic acid are reacted with 13.8 g of hydroxylamine hydrochloride in the manner described in Example 4. Crystallisation from CH2Cl2 /CH3OH/ether/hexane yields 2-(3-BOC-methylaminophenyl)-2-hydroxyiminoacetic acid. M.p. 135° (decomposition). IR: 3620, 3600-2300 (wide), 1688, 1600, 1590 (shoulder) cm-1 (CH2Cl2).

Workup

customCrystallisation from CH2Cl2 /CH3OH/ether/hexane

Sources & evidence

ORD record: ord-d3069b006f5c4617b762822454a9478d
Source dataset: uspto-grants-1984_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04464366

Reaction notes

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