Triethylamine → HCID 13090849, compound

HRID 358181Notes

Reaction equation

HRID 358181 reaction equation
C(N(CC)CC)C.[C:8]([O:11][CH2:12][C:13](Cl)=[O:14])(=[O:10])[CH3:9].[F:16][C:17]([F:22])([F:21])[CH2:18][NH:19][CH3:20]>C1(C)C=CC=CC=1>[F:16][C:17]([F:22])([F:21])[CH2:18][N:19]([CH3:20])[C:13](=[O:14])[CH2:12][O:11][C:8](=[O:10])[CH3:9]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 26297Acetoxyacetyl chlorideHCID 5203012,2,2-trifluoro-N-methylethanamine

Product 1

HCID 13090849HCID 13090849, compoundYield 79.8%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
20 °C

Procedure

10 g (0.1 mol) of triethylamine and 13.6 g (0.1 mol) of acetoxyacetyl chloride were added to a solution of 9.9 g (0.1 mol) of N-(2,2,2-trifluoroethyl)-N-methylamine in 150 ml of toluene and the mixture was stirred at 20° C. for 15 hours. It was then filtered and the filtrate was distilled. 17 g (79.8% of theory) of N-(2,2,2-trifluoroethyl)-N-methyl-acetoxyacetamide of boiling point 110° C./3 mbar were obtained. ##STR11## was obtained analogously; ND20 :1.4333. ##STR12##

Workup

  1. filtrationIt was then filtered
  2. distillationthe filtrate was distilled

Sources & evidence

ORD record
ord-15424f31f2724765b605ee0a38e34833
Source dataset
uspto-grants-1984_08
Patent number
US04465504

Reaction notes

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