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The procedure of B. V. Cheney et al. [J. Med. Chem,, 28, 1853-1864 (1985)) was used. A solution of 4-(2-aminoethyl)morpholine (1.00 g, 76.8 mmol) and ethyl formate (213 mL, 2640 mmol) was refluxed overnight under an atmosphere of nitrogen. Vacuum distillation gave 11.46 g (100% yield) of a clear, colorless liquid (bP0.3 118°-120° C.). The 1H NMR spectral data were consistent with the structure of the title compound.

1. distillationVacuum distillation
2. customgave 11.46 g (100% yield) of a clear, colorless liquid (bP0.3 118°-120° C.)