反应详情

The reaction of ethyl α-cyclopentyl-α-phenylethynylglycolate (5.4 g., 0.02 mole), 1-methyl-4-piperidinol (3.5 g., 0.03 mole) and sodium (~0.05 g.) in about 85 ml. of toluene was carried out essentially as described in the preceding preparation. However, no solid precipitated upon the addition of 20°-40° petroleum ether at the end of the reflux period. The reaction mixture therefore was poured on ice and HCl and extracted with ether. The ether extracts were washed with dilute HCl. The washings and water layer were combined, made basic with sodium carbonate, and extracted with chloroform. Drying of the basic extract and subsequent distillation of the volatile compound in vacuo yielded a tarry residue which, when treated with ether and hexane gave 1.5 g. (22%) of crude product. The pure compound, m.p. 104°-105°, was obtained by recrystallization from hexane.

1. customas described in the preceding preparation
2. customHowever, no solid precipitated upon the addition of 20°-40° petroleum ether at the end of the reflux period
3. additionThe reaction mixture therefore was poured on ice and HCl
4. extractionextracted with ether
5. washThe ether extracts were washed with dilute HCl
6. extractionextracted with chloroform
7. customDrying of the
8. extractionbasic extract
9. distillationsubsequent distillation of the volatile compound in vacuo
10. customyielded a tarry residue which, when
11. customgave 1.5 g