Hydrochloric Acid → HCID 85608038, compound

HRID 358570Notes

Reaction equation

HRID 358570 reaction equation
[CH:1]1[CH:13]=[CH:12][C:11]2[CH2:14][CH2:15][N:9]3[C:10]=2[C:2]=1[C:3]1[C:4](=O)[CH2:5][CH2:6][CH2:7][C:8]=13.Cl.[NH2:18][OH:19].Cl>N1C=CC=CC=1>[CH:1]1[CH:13]=[CH:12][C:11]2[CH2:14][CH2:15][N:9]3[C:10]=2[C:2]=1[C:3]1[C:4](=[N:18][OH:19])[CH2:5][CH2:6][CH2:7][C:8]=13

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 443297Hydroxyamine hydrochlorideHCID 21859619HCID 21859619, compound

Product 1

HCID 85608038HCID 85608038, compoundYield 35.9%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 4,5,8,9-tetrahydropyrrolo[3,2,1-jk]carbazol-10(7H)-one (364 mg) and hydroxylamine hydrochloride (479 mg) in pyridine (50 ml) was heated to 50° for 60 h, and was then poured into 2N hydrochloric acid (100 ml). The resultant precipitate was filtered off, washed with water (50 ml), and dried in vacuo at 50° for 6 h to give the title compound (140 mg). Filtration of the precipitate that formed subsequently in the filtrate gave a further crop of the title compound (104 mg), m.p. 271°-272°.

Workup

  1. temperaturewas heated to 50° for 60 h
  2. filtrationThe resultant precipitate was filtered off
  3. washwashed with water (50 ml)
  4. customdried in vacuo at 50° for 6 h

Sources & evidence

ORD record
ord-e66f5ca84af74365a00da6eae1147c3d
Source dataset
uspto-grants-1991_03
Patent number
US04997831

Reaction notes

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