Ethyl isobutyrate → HCID 20066956, compound

HRID 358626Notes

Reaction equation

HRID 358626 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][Br:10].[CH2:11]([O:13][C:14](=[O:18])[CH:15]([CH3:17])[CH3:16])[CH3:12].C([N-]C(C)C)(C)C.[Li+]>CN(C)P(N(C)C)(N(C)C)=O>[CH3:16][C:15]([CH3:17])([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][Br:10])[C:14]([O:13][CH2:11][CH3:12])=[O:18]

Participants

5

Reactant 3

HCID 7342Ethyl isobutyrateHCID 783101,8-DibromooctaneHCID 2724682Lithium diisopropylamide

Product 1

HCID 20066956HCID 20066956, compoundYield 16.5%

Reagents, catalysts & solvents 1

HCID 12679HexamethylphosphoramideSolvent

Procedure

Using the method described in Example 5(i), 1,8-dibromooctane (27.2 g, 0.1 mol) and ethylisobutyrate (10.44 g, 0.09 mol) were reacted in the presence of lithium diisopropylamide (67 ml, 0.1 mol) and hexamethylphosphoramide (22 g) to give the title compound (4.56 g) as an oil.

Sources & evidence

ORD record
ord-1e8a137e661d40199c3c8e749e81cd5f
Source dataset
uspto-grants-1991_03
Patent number
US04997847

Reaction notes

Loading…