Iodoethane → HCID 67903479, compound

HRID 358728Notes

Reaction equation

HRID 358728 reaction equation
[CH2:1]([O:17][CH2:18][C@@H:19]1[CH2:23][O:22][C@@H:21]([CH2:24][O:25][C:26]([NH:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=2)=[O:27])[CH2:20]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[CH2:36]([I:38])[CH3:37]>C(#N)C>[I-:38].[CH2:36]([N+:31]1[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=1[CH2:29][NH:28][C:26]([O:25][CH2:24][C@H:21]1[CH2:20][C@H:19]([CH2:18][O:17][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[CH2:23][O:22]1)=[O:27])[CH3:37]

Participants

4

Reactant 2

HCID 6340IodoethaneHCID 67903441HCID 67903441, compound

Product 1

HCID 67903479HCID 67903479, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of the compound prepared in example 9 (0.3 g, 0.61 mmol) and ethyl iodide (2 mL) dissolved in acetonitrile (1 mL) was refluxed under argon atmosphere for 12 h. The mixture was permitted to cool, the solvent was evaporated in vacuo and the residue was recrystallized with dichloromethane and diethyl ether to yield 0.36 g of the title compound of this example as a yellowish solid (90% yield).

Workup

  1. temperaturewas refluxed under argon atmosphere for 12 h
  2. temperatureto cool
  3. customthe solvent was evaporated in vacuo
  4. customthe residue was recrystallized with dichloromethane and diethyl ether

Sources & evidence

ORD record
ord-31dfa86573994afa9dd763be8652a570
Source dataset
uspto-grants-1991_03
Patent number
US04997843

Reaction notes

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