反应详情

To a stirred solution of 2-nitro-N-tert-butylaniline (37 g) and triethylamine (35 ml) in tetrahydrofuran (400 ml) was added dropwise a solution of ethoxalyl chloride (25 ml) in tetrahydrofuran (50 ml). The mixture was then brought to reflux temperature for 8 h. The solvent was removed by evaporation, and the residue was partitioned between ether (300 ml) and water (500 ml). The organic phase was washed twice with water, dried over Na2SO4 and evaporated. This left the title compound as light yellow crystals, m.p. 73°-74° C.

1. temperatureto reflux temperature for 8 h
2. customThe solvent was removed by evaporation
3. customthe residue was partitioned between ether (300 ml) and water (500 ml)
4. washThe organic phase was washed twice with water
5. dry with materialdried over Na2SO4
6. customevaporated
7. waitThis left the title compound as light yellow crystals, m.p. 73°-74° C.