Triethylamine → HCID 14853717, compound

HRID 358962Notes

Reaction equation

HRID 358962 reaction equation
[NH2:1][C:2]1[C:3]([NH:8][CH:9]([CH3:11])[CH3:10])=[N:4][CH:5]=[CH:6][CH:7]=1.C(N(CC)CC)C.[C:19](Cl)([C:21](OCC)=[O:22])=[O:20]>O1CCCC1>[CH:9]([N:8]1[C:19](=[O:20])[C:21](=[O:22])[NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[N:4][C:3]1=2)([CH3:11])[CH3:10]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 20884Ethoxalyl chlorideHCID 21818971N~2~-(Propan-2-yl)pyridine-2,3-diamine

Product 1

HCID 14853717HCID 14853717, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of 3-amino-2-isopropylamino-pyridine (2.0 g, 10.6 mmole) and triethylamine (4.8 ml, 34.6 mmole) in tetrahydrofuran (30 ml) was dropwise added ethoxalyl chloride (2.68 ml, 24 mmole). Stirring was continued for two hours after the addition. The mixture was filtered through a glass filter funnel and the filtrate was evaporated to give the title compound as white crystals. M.p. 246°-24720 C.

Workup

  1. additionafter the addition
  2. filtrationThe mixture was filtered through a glass
  3. filtrationfilter funnel
  4. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-b5c02089c05a407187b61ca660891a78
Source dataset
uspto-grants-1991_03
Patent number
US04999354

Reaction notes

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