Hydrochloric Acid → 126167-33-7

HRID 358967Notes

Reaction equation

HRID 358967 reaction equation
[ClH:1].Cl.[NH2:3][CH2:4][CH2:5][C:6]1[N:10]=[CH:9][NH:8][CH:7]=1.[OH-].[K+].[C:13]([OH:17])(=[O:16])[CH:14]=O.O.[K].Cl>O>[ClH:1].[ClH:1].[NH:10]1[C:6]2[CH2:5][CH2:4][NH:3][CH:14]([C:13]([OH:17])=[O:16])[C:7]=2[N:8]=[CH:9]1

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 5462222PotassiumHCID 15620607Glyoxylic acid, monohydrateHCID 178478691HCID 178478691, compound

Product 1

HCID 67945944126167-33-7

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
90 °C

Procedure

25.00 g (0.135 moles) of histamine dihydrochloride were dissolved in 125 ml of water; 26.92 g (0.40 moles) of 85% potassium hydroxide were then added to the cooled solution. A solution of 12.51 g (0.136 moles) of monohydrate glyoxylic acid and 9.00 g (0.136 moles) of 85% potassium hydroxyde in 125 ml of water was dropped into the first one and the reaction mixture heated at 90° C., 6 hours, cooled, treated with conc. HCl and concentrated in vacuo to dryness.

Workup

  1. temperaturecooled
  2. concentrationconcentrated in vacuo to dryness

Sources & evidence

ORD record
ord-0a44ffc5edc54a61b6d82e57a8b23284
Source dataset
uspto-grants-1991_03
Patent number
US04999359

Reaction notes

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