Toluene → HCID 20064754, compound

HRID 359271Notes

Reaction equation

HRID 359271 reaction equation
[CH3:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[C:3]=1[NH2:4].[C:10]1(C)C=CC=C[CH:11]=1.Cl[C:18]1[O:19][C:20]([C:27]([O-:29])=[O:28])=[C:21]([C:23]([F:26])([F:25])[F:24])[N:22]=1>>[CH3:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[C:3]=1[NH:4][C:18]1[O:19][C:20]([C:27]([O:29][CH2:10][CH3:11])=[O:28])=[C:21]([C:23]([F:26])([F:25])[F:24])[N:22]=1

Participants

4

Reactant 3

HCID 1140TolueneHCID 68962,6-DimethylanilineHCID 20064765HCID 20064765, compound

Product 1

HCID 20064754HCID 20064754, compound

Procedure

By the procedure of Example 15, 4.84 g (0.04 mol) of 2,6-dimethyl aniline was added to a stirred solution of 75 ml toluene containing 4.87 g (0.02 mol) of 2-chloro-4-trifluoromethyl-5-oxazolecarboxylate. The reaction mixture was stirred at reflux for 24 hours. The product was separated, distilled and then recrystallized from petroleum ether to yield 1.99 g of crystal product (m.p.=79°-81° C.) identified in Table I.

Workup

  1. temperatureat reflux for 24 hours
  2. customThe product was separated
  3. distillationdistilled
  4. customrecrystallized from petroleum ether

Sources & evidence

ORD record
ord-fefb4c7c3dc4406e86196c5e5892ed4c
Source dataset
uspto-grants-1991_03
Patent number
US05000775

Reaction notes

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