反应详情

To a stirred and refluxed Grignard complex previously prepared starting from a mixture of 4.2 parts of 1-bromo-3-chlorobenzene, 5.4 parts of magnesium and 135 parts of tetrahydrofuran were added dropwise 19 parts of 1-(phenylmethyl)-3-piperidinone. Upon completion, stirring was continued for 1 hour at reflux temperature. After cooling, the reaction mixture was poured into ice water and 12.5 parts of acetic acid. The layers were separated. The aqueous phase was extracted with trichloromethane. The organic layer was washed with water, dried, filtered and evaporated. The residue was converted into the hydrochloride salt in 2-propanol. The salt was filtered off and dried, yielding 26 parts (76%) of 3-(3-chlorophenyl)-1-(phenylmethyl)-3-piperidinol hydrochloride (intermediate 27).

1. temperaturerefluxed Grignard complex
2. custompreviously prepared
3. stirringUpon completion, stirring
4. temperatureat reflux temperature
5. temperatureAfter cooling
6. customThe layers were separated
7. extractionThe aqueous phase was extracted with trichloromethane
8. washThe organic layer was washed with water
9. customdried
10. filtrationfiltered
11. customevaporated
12. filtrationThe salt was filtered off
13. customdried