反应详情

2-Furanethanol (2 g) in DMF (5 ml) was added dropwise to a suspension of sodium hydride (0.43 g) in DMF (20 ml). The mixture was stirred for 30 min and added dropwise to 1,6-dibromohexane (21.8 g). The resulting suspension was heated at 60°-70° for 18 h, poured into water (200 ml) and extracted with diethyl ether (3×100 ml). The dried extract was evaporated and the residue was purified on a column of silica eluted with cyclohexane. The resulting oil was fractionally distilled (Kugelrohr) to give the title compound as a colourless oil (1.7 g) b.p. 75°-80°/0.3 Torr.

1. temperatureThe resulting suspension was heated at 60°-70° for 18 h
2. extractionextracted with diethyl ether (3×100 ml)
3. extractionThe dried extract
4. customwas evaporated
5. customthe residue was purified on a column of silica
6. washeluted with cyclohexane
7. distillationThe resulting oil was fractionally distilled (Kugelrohr)