Tetrahydrofuran →

HRID 359894Notes

Reaction equation

[Cl:1][CH2:2][CH2:3][N:4]([N:19]=[O:20])[C:5]([NH:7][CH2:8][CH2:9][O:10]C(C1C=NC=CC=1)=O)=[O:6].[I-:21].[O:22]1[CH2:26][CH2:25][CH2:24][CH2:23]1>>[I-:21].[Cl:1][CH2:2][CH2:3][N:4]([N:19]=[O:20])[C:5]([NH:7][CH2:8][CH2:9][O:10][C:26]([CH:25]1[CH2+:24]=[CH:23][CH:2]=[CH:3][N:4]1[CH3:5])=[O:22])=[O:6]

Participants

Reactant 3

HCID 8028Tetrahydrofuran

HCID 30165Iodide Ion

HCID 15680044N-(2-Chloroethyl)-N'-[2-(3-pyridinecarbonyloxy)ethyl]-N-nitrosourea

Product 0

No Product data yet.

Conditions

Temperature: 50 °C

Procedure

A solution of the product of Example 122 (1.5 g, 5 mmol) in 40 mL of tetrahydrofuran was treated with excess iodide. The mixture was stirred at 50° C. for 4 hours. The finely crystalline, yellow solid thus obtained (1.8 g, 82%) melted at 120°-121° C. and had the structure ##STR153## as confirmed by elemental analysis.

Workup

customThe finely crystalline, yellow solid thus obtained (1.8 g, 82%) melted at 120°-121° C.

Sources & evidence

ORD record: ord-5375fcb3b4934380b1154b7b5222d081
Source dataset: uspto-grants-1991_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05002935

Reaction notes

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