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HRID35993

反应详情

EQUATION

反应方程式

HRID 35993 的结构方程式

REACTANTS

反应物

4
结构：COC(=O)c1ccc(O)cc1
HCID7456

Methylparaben

C8H8O3

2 次

结构：CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1
HCID27447

Cephalexin

C16H17N3O4S

结构：CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1.O
HCID62921

Cephalexin monohydrate

C16H19N3O5S

结构：[F-].[K+]
HCID522689

Potassium fluoride

FK

PRODUCTS

生成物

1
结构：COC(=O)c1ccc(O)cc1.O
HCID67689272

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

2 次

PROCEDURE

实验过程

Methyl paraben (375 mg, 2.5 mmol) in 150 ml of water was added to cephalexin monohydrate (2.4 g, 6.6 mmol) to result in a suspension. After 5 days at 5° C., the crystals were collected by filtration and washed with water to give 1.06 g (2.0 mmol) of cocrystals. mp 168°-169° C. Anal. calcd for C24H25N3O7S·H2O: C, 55.70; H, 5.26; N, 8.12. Found: C, 55.65; H, 5.28; N, 8.13. HPLC assay (calcd), found: (67.1), 67.1% cephalexin, (29.4), 28.7% methyl paraben. KF (Calcd) , found: (3.5) , 4.0% water.

WORKUP

后处理

  1. customto result in a suspension
  2. filtrationthe crystals were collected by filtration
  3. washwashed with water
  4. customto give 1.06 g (2.0 mmol) of cocrystals