Methyl iodide → 8-Ethoxycarbonyl-3-methoxy-2-methyl-1-oxa-8-azaspiro[4,5]decane
Reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:17][CH2:16][C:9]2([O:13][CH:12]([CH3:14])[CH:11]([OH:15])[CH2:10]2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].[H-].[Na+].[CH3:20]I>CN(C)C=O>[CH2:1]([O:3][C:4]([N:6]1[CH2:7][CH2:8][C:9]2([O:13][CH:12]([CH3:14])[CH:11]([O:15][CH3:20])[CH2:10]2)[CH2:16][CH2:17]1)=[O:5])[CH3:2]Participants
Procedure
A solution of 93 mg 8-ethoxycarbonyl-3-hydroxy-2-methyl-1-oxa-8-azaspiro[4,5]decane in 1 ml N,N-dimethylforamide was cooled in ice, 16.7 mg oily sodium hydride (60%) was added, and the resulting mixture was stirred for 30 minutes under ice cooling. Methyl iodide (26.2 μl) was then added, and the mixture was stirred at room temperature for about 24 hours and poured into 5 ml ice water. After extraction with chloroform, the extract was washed with an aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure from the dried solution, and the residue was purified by silica gel column chromatography using, as eluent, a mixed solvent of ethyl acetate/n-hexane (1:1 by volume), giving 47 mg 8-ethoxycarbonyl-3-methoxy-2-methyl-1-oxa-8-azaspiro[4,5]decane as oil.
Workup
- stirringthe mixture was stirred at room temperature for about 24 hours
- extractionAfter extraction with chloroform
- washthe extract was washed with an aqueous solution of sodium chloride
- dry with materialdried over anhydrous magnesium sulfate
- distillationThe solvent was distilled off under reduced pressure from the dried solution
- customthe residue was purified by silica gel column chromatography
Sources & evidence
- ORD record
- ord-82749a2e89404ea492a9ceb5eb566edd
- Source dataset
- uspto-grants-1995_05
- Patent number
- US05412096
Reaction notes
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