Pyridine → 1,8-Diazabicyclo(5.4.0)undec-7-ene

HRID 36095Notes

Reaction equation

HRID 36095 reaction equation
ClC([O-])=O.[N:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C1COCC1>[CH2:8]1[CH2:9][CH2:10][N:5]2[C:10](=[N:5][CH2:6][CH2:7][CH2:8]2)[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 1049PyridineHCID 21226386Carbonochloridate

Product 1

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Compounds of Formula (I) wherein R1 is --SO2NHCO2R24 may be prepared by reacting an appropriate chloroformate with the sulfonamide (29) in pyridine or in the presence of DBU in THF to afford the desired compound (41), as outlined in Scheme 11. ##STR99##

Workup

  1. custommay be prepared

Sources & evidence

ORD record
ord-69ba83aa8bc149259cd0e77a969c6e15
Source dataset
uspto-grants-1995_05
Patent number
US05412097

Reaction notes

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