反应详情

Sodium cyanoborohydride (2 g) was added portionwise to a stirred mixture of 4-bromo-2-thiophenecarbaldehyde (4.78 g), morpholine (2.1 g), glacial acetic acid (1.8 g) and ethanol (125 ml). The mixture was stirred at ambient temperature for 1 hour. The mixture was poured into a saturated aqueous sodium bicarbonate solution and extracted with methylene chloride. The organic phase was washed with brine and evaporated. The resultant oil was partitioned between a dilute (10%) aqueous hydrochloric acid solution and methylene chloride. The aqueous phase was basified by the addition of a saturated aqueous sodium bicarbonate solution and extracted with methylene chloride. The organic extract was dried (MgSO4) and evaporated to give 4-bromo-2-morpholinomethylthiophene (3.2 g);

1. extractionextracted with methylene chloride
2. washThe organic phase was washed with brine
3. customevaporated
4. customThe resultant oil was partitioned between
5. additiona dilute (10%) aqueous hydrochloric acid solution and methylene chloride
6. additionThe aqueous phase was basified by the addition of a saturated aqueous sodium bicarbonate solution
7. extractionextracted with methylene chloride
8. extractionThe organic extract
9. dry with materialwas dried (MgSO4)
10. customevaporated