反应详情

温度

50 °C

1-Acetyl-5-nitro-indoline (1.00 g, 4.85 mmol) was added to borane-THF complex 1M, 10 mL, 10 mmol). The mixture was heated at reflux for 4 h. With ice-water bath cooling, the mixture was slowly reated with 6N HCl (4 mL). Then the mixture was heated at 50° C. for 1 h. The organic solvent was evaporated off and the resulting suspension was filtered to give an orange solid (1.02 g) which was washed with water: mp 97°-98° C.

1. temperatureThe mixture was heated
2. temperatureat reflux for 4 h
3. temperatureWith ice-water bath cooling
4. customThe organic solvent was evaporated off
5. filtrationthe resulting suspension was filtered