反应详情

A mixture of 3-(5,6-dihydroxyhexyl)-1-methyluracil (350 mg, 1.4 mmol) and a 30% solution of hydrogen bromide in acetic acid (0.87 mL, 4.3 mmol) was stirred for 45 minutes. The mixture was then added to a mixture of sodium bicarbonate (1.6 g), water (10 mL) and dichloromethane (20 mL). After 15 minutes of vigorous stirring, the layers were separated and the aqueous layer extracted with dichloromethane (3×40 mL). The combined organic layers were dried over sodium sulfate, then evaporated under vacuum to give 3-(5-acetoxy-6-bromohexyl)-1-methyluracil (500 mg, 100% yield).

1. customthe layers were separated
2. extractionthe aqueous layer extracted with dichloromethane (3×40 mL)
3. dry with materialThe combined organic layers were dried over sodium sulfate
4. customevaporated under vacuum