Phenethylamine → HCID 2450326, compound

HRID 361597Notes

Reaction equation

HRID 361597 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([O:9]CC)=O.[CH2:12]([NH2:20])[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(O)C>[CH2:12]([NH:20][C:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[O:9])[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 1001PhenethylamineHCID 17307Ethyl 2-pyridinecarboxylate

Product 1

HCID 2450326HCID 2450326, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 20 ml of ethyl pyridine-2-carboxylate and 27 ml of phenethylamine was stirred at 180° C. for 5 h., with the ethanol formed being distilled off over a 30 cm Vigreux column. Distillation of the residue yielded 30.9 g of pyridine-2-carboxylic acid phenethyl-amide as a yellowish oil, b.p. 150°-155° C./0.8 mbar.

Workup

  1. customformed
  2. distillationbeing distilled off over a 30 cm Vigreux column
  3. distillationDistillation of the residue

Sources & evidence

ORD record
ord-ebdf5ff3e2cc450aac0103a139a62c9f
Source dataset
uspto-grants-1999_02
Patent number
US05866583

Reaction notes

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