Phenyl chloroformate → HCID 53993001, compound

A suspension of 1.2 g (50 mmol) of 60% sodium hydride in 100 ml of anhydrous DMF was prepared. A solution of 9.2 g (45.3 mmol) of methyl 4,7-dimethylindole-2-carboxylate in 150 ml of anhydrous DMF was added dropwise thereto over a period of 1 hour. The reaction mixture was stirred at room temperature for 1 hour and then cooled to 0° C. A solution of 6.25 ml (50.0 mmol) of phenyl chlorocarbonate in 20 ml of anhydrous DMF was added dropwise over a period of 30 minutes. The reaction mixture was stirred at room temperature for 15 hours and then added dropwise to 800 ml of ice water. The reaction mixture was extracted with 200 ml of ethyl acetate three times. The ethyl acetate layers were combined, washed with 300 ml of water twice and dried over anhydrous magnesium sulfate. After the ethyl acetate layers were distilled off under reduced pressure, the residue was recrystallized from acetone to provide 1.50 g of light yellow crystals. Yield: 10%

1. customwas prepared
2. temperaturecooled to 0° C
3. stirringThe reaction mixture was stirred at room temperature for 15 hours
4. extractionThe reaction mixture was extracted with 200 ml of ethyl acetate three times
5. washwashed with 300 ml of water twice
6. dry with materialdried over anhydrous magnesium sulfate
7. distillationAfter the ethyl acetate layers were distilled off under reduced pressure
8. customthe residue was recrystallized from acetone

ORD record

ord-53e1efc94ce84aff8d5442e3d23db954

Source dataset

uspto-grants-1999_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05866594