反应详情

Preparation of 2-chloro-6-(4-methoxybenzylamino)-9-isopropylpurine (2) The 6-(4-methoxybenzylamino)-2-chloropurine (496 mg, 1.7 mmol) was suspended in dry DMF (5 ml) and treated with sodium hydride, 60% dispersion (82 mg, 2.06 mmol). The suspension was stirred for 30 min over which time it became a clear yellow/green solution. 2-Iodopropane (0.280 mL, 1.7 eq.) was added over 5 min and the resultant solution stirred for 2 days. Water was added and the solution and extracted with ethyl acetate. The organic layer was evaporated to give the product isopropyl purine (508 mg, 89%).

1. extractionthe solution and extracted with ethyl acetate
2. customThe organic layer was evaporated