1,8-Diazabicyclo(5.4.0)undec-7-ene → Ethyl 2-(4-acetoxyphenyl)-3-(5-cyano-2-benzofuranyl)acrylate
Reaction equation
[Cl-].[C:2]([C:4]1[CH:5]=[CH:6][C:7]2[O:11][C:10]([CH2:12][P+](C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)=[CH:9][C:8]=2[CH:32]=1)#[N:3].[C:33]([O:36][C:37]1[CH:42]=[CH:41][C:40]([C:43](=O)[C:44]([O:46][CH2:47][CH3:48])=[O:45])=[CH:39][CH:38]=1)(=[O:35])[CH3:34].C1CCN2C(=NCCC2)CC1>O1CCCC1.C(O)C>[C:33]([O:36][C:37]1[CH:42]=[CH:41][C:40]([C:43](=[CH:12][C:10]2[O:11][C:7]3[CH:6]=[CH:5][C:4]([C:2]#[N:3])=[CH:32][C:8]=3[CH:9]=2)[C:44]([O:46][CH2:47][CH3:48])=[O:45])=[CH:39][CH:38]=1)(=[O:35])[CH3:34]Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Procedure
15.93 g of (5-cyano-2-benzofuranyl)methyltriphenylphosphonium chloride and 8.29 g of ethyl 2-(4-acetoxyphenyl)-2-oxoacetate were dissolved in a mixture solution of 80 ml of tetrahydrofuran and 80 ml of ethanol. At room temperature, 5.34 g of 1,8-diazabicyclo[5.4.0]-7-undecene was added to the above solution, and the mixture was stirred for 18 hours at the same temperature. The resulting reaction solution was concentrated to dryness, and the residue was purified by silica gel column chromatography using a toluene/ethyl acetate mixture as an eluant to obtain 11.28 g of ethyl 2-(4-acetoxyphenyl)-3-(5-cyano-2-benzofuranyl)acrylate in the form of light yellow crystals as a mixture of E and Z forms.
Workup
- customThe resulting reaction solution
- concentrationwas concentrated to dryness
- customthe residue was purified by silica gel column chromatography
Sources & evidence
- ORD record
- ord-40006dedb6b54c95b84cea1d60297a1a
- Source dataset
- uspto-grants-1999_02
- Patent number
- US05866577
Reaction notes
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