反应详情

Anisole (2 drops) was added to a solution of 5-n-butyl-4-[[2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl]-2,4-dihydro-2-isopropyl-3H-1,2,4-triazol-3-one (from Step H) (97.5 mg; 0.201 mmole) in 2 ml of trifluoroacetic acid stirred under N2 at room temperature. After 24 hours, the solution was concentrated in vacuo. Chromatography of the residue on silica gel (gradient elution with 1.5 to 2% MeOH in CH2Cl2, containing 0.2% concentrated ammonium hydroxide) afforded 67.4 mg (78%) of the title compound as a white solid; satisfactory purity by TLC in 98:2:0.2 CH2Cl2 --MeOH-concd. NH4OH; mass spectrum (FAB) m/e 429 (M+1)+.

1. concentrationthe solution was concentrated in vacuo