Propylamine → HCID 32911, compound

HRID 362170Notes

Reaction equation

HRID 362170 reaction equation
[N:1]1[C:8]([Cl:9])=[N:7][C:5](Cl)=[N:4][C:2]=1[Cl:3].C(=O)([O-])O.[K+].[CH2:15]([NH2:18])[CH2:16][CH3:17]>CC(C)=O.O>[Cl:9][C:8]1[N:1]=[C:2]([Cl:3])[N:4]=[C:5]([NH:18][CH2:15][CH2:16][CH3:17])[N:7]=1

Participants

6

Reactant 3

HCID 7852PropylamineHCID 7954Cyanuric chloride2×HCID 516893Potassium Bicarbonate

Product 1

HCID 32911HCID 32911, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

Cyanuric chloride (1) (36.9 g, 0.2 mole) was dissolved in acetone (600 ml) and cooled in an ice/acetone bath. Potassium hydrogen carbonate (25.03 g, 0.25 mole) was dissolved in water (150 ml) with propylamine (11.82 g, 0.2 mole) and added dropwise to the solution of (1) while maintaining the temperature below 0° C. The mixture was stirred for 1 hour at 0° C. and then stirred for 1 hour at room temperature. The acetone was evaporated off under reduced pressure and the residue (300 ml) was poured into water (11). The resulting white solid was filtered, washed with water and dried under vacuum.

Workup

  1. temperaturecooled in an ice/acetone bath
  2. temperaturewhile maintaining the temperature below 0° C
  3. stirringstirred for 1 hour at room temperature
  4. customThe acetone was evaporated off under reduced pressure
  5. additionthe residue (300 ml) was poured into water (11)
  6. filtrationThe resulting white solid was filtered
  7. washwashed with water
  8. customdried under vacuum

Sources & evidence

ORD record
ord-fb60067b72924a4bbe4e9abf7372dc8c
Source dataset
uspto-grants-1999_02
Patent number
US05869222

Reaction notes

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