反应详情

A mixture of 0.291 g of 6,11-dihydro-5H-dibenz[b,e]azepine, 0.518 g of 4-[N-methyl-N-(2-methylbenzoyl)amino]benzoyl chloride and 0.182 g of triethylamine in 10 ml of tetrahydrofuran is stirred at room temperature for 2 hours. The solvent is removed, the residue diluted with water and extracted with dichloromethane. The extract is washed with 1N HCl water, 1M NaHCO3, brine and dried (Na2SO4). The solution is passed through a thin pad of hydrous magnesium silicate. The filtrate is concentrated and chilled to give 0.52 g of crystals, m.p. 160°-170° C.

1. customThe solvent is removed
2. additionthe residue diluted with water
3. extractionextracted with dichloromethane
4. washThe extract is washed with 1N HCl water, 1M NaHCO3, brine
5. dry with materialdried (Na2SO4)
6. concentrationThe filtrate is concentrated
7. temperaturechilled